%20--%3e%3csvg%20version='1.1'%20id='Ebene_1'%20xmlns='http://www.w3.org/2000/svg'%20xmlns:xlink='http://www.w3.org/1999/xlink'%20x='0px'%20y='0px'%20viewBox='0%200%20897.61%20762.46'%20style='enable-background:new%200%200%20897.61%20762.46;'%20xml:space='preserve'%3e%3cstyle%20type='text/css'%3e%20.st0{fill:%2305171D;}%20%3c/style%3e%3cg%3e%3cpath%20class='st0'%20d='M211.66,376.86h-2.38c-7.13,27.08-34.67,47.52-66.99,47.52c-63.19,0-95.97-46.1-95.97-130.67%20c0-84.58,32.78-130.19,95.97-130.19c32.32,0,59.86,19.96,66.99,47.51h2.38V67.07h70.32v351.61h-70.32V376.86z%20M211.66,330.78%20v-73.64c0-22.81-19.48-36.59-46.09-36.59s-46.09,20.43-46.09,51.8v43.24c0,31.36,19.48,51.79,46.09,51.79%20S211.66,353.58,211.66,330.78'/%3e%3cpath%20class='st0'%20d='M352.28,223.87h-35.16v-54.64h35.16v-29.46c0-48,26.13-72.7,74.6-72.7h45.61v54.65h-49.9v47.51h49.9v54.64%20h-49.9v194.81h-70.32V223.87z'/%3e%3cpolygon%20class='st0'%20points='503.46,67.07%20573.78,67.07%20573.78,274.71%20576.63,274.71%20607.53,228.62%20657.41,169.23%20735.33,169.23%20652.19,264.73%20744.83,418.67%20661.21,418.67%20605.14,313.2%20573.78,348.36%20573.78,418.67%20503.46,418.67%20'/%3e%3crect%20x='773.37'%20y='169.22'%20class='st0'%20width='70.32'%20height='249.45'/%3e%3cpath%20class='st0'%20d='M808.53,52.95c20.96,0,38.01,17.05,38.01,38.01c0,20.96-17.05,38.01-38.01,38.01%20c-20.95,0-38.01-17.05-38.01-38.01C770.52,70,787.58,52.95,808.53,52.95%20M808.53,48.2c-23.61,0-42.76,19.15-42.76,42.76%20c0,23.61,19.15,42.76,42.76,42.76c23.61,0,42.76-19.15,42.76-42.76C851.29,67.35,832.14,48.2,808.53,48.2'/%3e%3cpath%20class='st0'%20d='M838.94,703.81h-60.82V463.87h60.82V703.81z%20M843.69,459.11h-70.32v249.45h70.32V459.11z'/%3e%3cg%3e%3cpath%20class='st0'%20d='M712.05,653.92V544.64c0-58.92-36.11-91.22-106.44-91.22c-52.26,0-80.77,18.05-100.72,47.51l41.81,37.06%20c10.93-15.2,25.66-29.46,53.69-29.46c29.46,0,41.33,15.2,41.33,39.43v15.68h-39.42c-66.06,0-106.91,25.19-106.91,77.93%20c0,43.24,27.56,72.69,77.44,72.69c35.05,0,63.89-13.96,74.36-39.92h2.38c6.68,21,22.97,34.22,44.93,34.22h40.83v-54.64H712.05z%20M730.58,703.81H694.5c-20.72,0-36.15-13.03-41.53-34.22h-1.73h-1.27h-0.82h-3.21h-1.77c-8.71,25.38-36.29,39.92-71.34,39.92%20c-45.52,0-72.69-25.39-72.69-67.94c0-60.48,55.55-73.18,102.16-73.18h39.42h4.75v-4.75v-15.68c0-28.91-15.94-44.19-46.09-44.19%20c-28.04,0-43.84,13.77-54.39,27.23l-34.78-30.83c21.11-29.03,50.43-42.02,94.4-42.02c66.53,0,101.69,29.9,101.69,86.47v109.29%20v4.75h4.75h18.53V703.81z'/%3e%3cpath%20class='st0'%20d='M646.47,603.56v-4.75h-4.75h-34.21c-40.1,0-46.09,20.54-46.09,32.78v7.13c0,11.71,4.87,31.36,37.53,31.36%20c29.3,0,47.51-14.21,47.51-37.06V603.56z%20M641.72,633.02c0,22.81-19.48,32.31-42.76,32.31c-20.9,0-32.78-8.55-32.78-26.61v-7.13%20c0-18.05,14.25-28.03,41.34-28.03h34.21V633.02z'/%3e%3c/g%3e%3c/g%3e%3c/svg%3e)
Expertise · Medical Image Registration
Deep Learning-based Medical Image Registration
Align medical image sequences across time, patients and imaging modalities with AI-powered registration technology for longitudinal analysis, therapy monitoring and next-generation diagnostic systems.
Why It Matters
Why Medical Image Registration Matters
Medical images acquired over time rarely align perfectly. Patient movement, respiratory motion, anatomical changes and different imaging devices introduce variability that limits reliable comparison.
DFKI develops deep learning-based medical image registration technologies that accurately align MRI, CT, PET and other medical images, enabling clinicians and AI systems to detect meaningful temporal and structural changes with greater confidence.
Selected DFKI research directions
From raw image sequences to aligned, AI-ready data.
Longitudinal Patient Monitoring
Register MRI or CT scans acquired months or years apart to accurately assess disease progression and therapy response.
Multi-modal Image Registration
Align CT, MRI, PET and other imaging modalities into a common spatial representation for improved diagnosis and AI-assisted analysis.
Motion Correction & Temporal Analysis
Correct respiratory and cardiac motion while enabling quantitative analysis of dynamic anatomical changes.
Challenges We Solve
Where medical image registration is genuinely hard.
Robust AI medical image registration has to hold up under scanner drift, patient motion and years of follow-up imaging. These are the recurring challenges our research addresses.
High variability between patients, scanners and imaging protocols
Motion artefacts caused by respiration and cardiac cycles
Robust longitudinal alignment across follow-up examinations
Morphological changes during therapy monitoring
Multi-modal image fusion challenges
Reliable image alignment for AI model development
Our Expertise
Deep learning registration, tuned to clinical reality.
DFKI combines longitudinal, temporal and multi-modal registration methods with quantitative change analysis to support radiology, cardiology and oncology partners.
Longitudinal Image Registration
Robust alignment across multiple patient examinations to support disease progression analysis and long-term monitoring.
Temporal Image Alignment
Accurate registration of dynamic image sequences for cardiac motion, respiratory movement and functional imaging.
Quantitative Change Analysis
Measure clinically meaningful changes including tumor growth, tissue remodeling, organ deformation and therapy response.
Multi-modal Registration
Combine MRI, CT, PET and additional imaging modalities into unified datasets for AI-assisted diagnostics and clinical decision support.
Business Impact
What partners get from AI medical image registration.
From MedTech R&D to hospital innovation teams, reliable image alignment unlocks better temporal AI models, faster diagnostic development and stronger evidence in clinical trials.
Accelerate AI-powered diagnostic development
Improve longitudinal disease monitoring
Support clinical trials and therapy development
Enable reliable multi-modal AI solutions
Reduce manual image alignment effort
Build robust temporal AI models beyond static image snapshots
Typical Applications
Where DFKI registration research is applied.
Longitudinal imaging, therapy monitoring AI and multi-modal image registration span most clinical and industrial imaging domains.
Why DFKI
A trusted European partner for healthcare AI innovation.
DFKI is one of the world's largest AI research centers, with vendor-independent expertise across medical imaging AI, longitudinal imaging and therapy monitoring AI.
1,500+
AI researchers
35+
Years of AI research
Publicly funded
Independent research
European
Research excellence
Related Expertise & Services
Where medical image registration connects.
Registration rarely stands alone — pair it with segmentation, radiology AI and consulting to move from research to deployed diagnostic systems.
Medical Image Analysis
Segmentation, classification and multimodal medical image analysis for diagnostics and research.
Learn moreMedical AI Solutions
Applied medical AI across imaging, diagnostics and clinical workflows — including segmentation and radiology.
Learn moreHealthcare AI Consulting
Strategic guidance for hospitals, MedTech and pharma teams building imaging AI and diagnostic systems.
Learn moreBuild More Reliable Medical Imaging AI
Whether you're developing imaging software, AI diagnostics, clinical decision support systems or next-generation medical devices, DFKI helps transform complex medical image sequences into robust, AI-ready datasets and clinically valuable insights.